articleTheranosticsJan 1, 2023GOLD OA

Hyperactive neuronal autophagy depletes BDNF and impairs adult hippocampal neurogenesis in a corticosterone-induced mouse model of depression

KZKuo ZhangFWFan WangMZMengying ZhaiMHMei-yao HeYHYuxuan Hu

Shenyang Pharmaceutical University

PubMed
Indexed incrossrefdoajpubmed

Abstract

Our findings reveal a neuronal autophagy-dependent mechanism that links chronic CORT to reduced neuronal BDNF levels, AHN suppression and depressive-like behavior in mice. In addition, our results provide insights for treating depression by targeting neuronal autophagy in the DG of the hippocampus.

Citation impact

195
total citations
FWCI
37.31
Percentile
100%
References
44
Citations per year

Authors

9

Topics & keywords

Topics
Keywords
  • Neurogenesis
  • Dentate gyrus
  • Neural stem cell
  • Hippocampal formation
  • Autophagy
  • Neurotrophic factors
  • Hippocampus
  • ATG5
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