Single-cell spatial landscapes of the lung tumour immune microenvironment
McGill University · University of Toronto · +6 more institutions
Abstract
Abstract Single-cell technologies have revealed the complexity of the tumour immune microenvironment with unparalleled resolution 1–9 . Most clinical strategies rely on histopathological stratification of tumour subtypes, yet the spatial context of single-cell phenotypes within these stratified subgroups is poorly understood. Here we apply imaging mass cytometry to characterize the tumour and immunological landscape of samples from 416 patients with lung adenocarcinoma across five histological patterns. We resolve more than 1.6 million cells, enabling spatial analysis of immune lineages and activation states with distinct clinical correlates, including survival. Using deep learning, we can predict with high…
Citation impact
- FWCI
- 58.44
- Percentile
- 100%
- References
- 57
Authors
25Topics & keywords
- Mass cytometry
- Tumour heterogeneity
- Context (archaeology)
- Immune system
- Biology
- Adenocarcinoma
- Lung cancer
- Tumor microenvironment