articleAdvanced MaterialsFeb 2, 2023BRONZE OA

A Thrombin‐Activated Peptide‐Templated Nanozyme for Remedying Ischemic Stroke via Thrombolytic and Neuroprotective Actions

ZWZhuoran WangYZYue ZhaoYHYaxin HouGTGuoheng TangRZRuofei Zhang

Chinese Academy of Sciences · Institute of Biophysics · +2 more institutions

PubMed
Indexed incrossrefpubmed

Abstract

Abstract Ischemic stroke (IS) is one of the most common causes of disability and death. Thrombolysis and neuroprotection are two current major therapeutic strategies to overcome ischemic and reperfusion damage. In this work, a novel peptide‐templated manganese dioxide nanozyme (PNzyme/MnO 2 ) is designed that integrates the thrombolytic activity of functional peptides with the reactive oxygen species scavenging ability of nanozymes. Through self‐assembled polypeptides that contain multiple functional motifs, the novel peptide‐templated nanozyme is able to bind fibrin in the thrombus, cross the blood–brain barrier, and finally accumulate in the ischemic neuronal tissues, where the thrombolytic motif is…

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194
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17.61
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100%
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61
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Authors

8

Topics & keywords

Topics
Keywords
  • Neuroprotection
  • Thrombolysis
  • Stroke (engine)
  • Ischemic stroke
  • Materials science
  • Thrombin
  • Peptide
  • Ischemia
UN Sustainable Development Goals
  • Good health and well-being
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