reviewJournal of HepatologyFeb 3, 2023HYBRID OA

An adipocentric perspective on the development and progression of non-alcoholic fatty liver disease

EYEun Young LeeHKHannelie KorfAVAntonio Vidal‐Puig

Chiba University · University of Cambridge · +5 more institutions

PubMed
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Abstract

Alongside the liver, white adipose tissue (WAT) is critical in regulating systemic energy homeostasis. Although each organ has its specialised functions, they must work coordinately to regulate whole-body metabolism. Adipose tissues and the liver are relatively resilient and can adapt to an energy surplus by facilitating triglyceride (TG) storage up to a certain threshold level without significant metabolic disturbances. However, lipid storage in WAT beyond a "personalised" adiposity threshold becomes dysfunctional, leading to metabolic inflexibility, progressive inflammation, and aberrant adipokine secretion. Moreover, the failure of adipose tissue to store and mobilise lipids results in systemic knock-on…

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188
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38.48
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100%
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207
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Authors

3

Topics & keywords

Topics
Keywords
  • Fatty liver
  • Steatohepatitis
  • Adipose tissue
  • Adipokine
  • Lipogenesis
  • Endocrinology
  • Internal medicine
  • White adipose tissue
UN Sustainable Development Goals
  • Affordable and clean energy
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