reviewInternational Journal of Molecular SciencesFeb 3, 2023GOLD OA

Triple-Negative Breast Cancer and Predictive Markers of Response to Neoadjuvant Chemotherapy: A Systematic Review

NSNadine S. van den EndeAHAnh H. NguyenAJAgnes JagerMKMarleen KokRDReno Debets

Erasmus MC Cancer Institute · The Netherlands Cancer Institute · +1 more institution

PubMed
Indexed incrossrefpubmed

Abstract

Around 40-50% of all triple-negative breast cancer (TNBC) patients achieve a pathological complete response (pCR) after treatment with neoadjuvant chemotherapy (NAC). The identification of biomarkers predicting the response to NAC could be helpful for personalized treatment. This systematic review provides an overview of putative biomarkers at baseline that are predictive for a pCR following NAC. Embase, Medline and Web of Science were searched for articles published between January 2010 and August 2022. The articles had to meet the following criteria: patients with primary invasive TNBC without distant metastases and patients must have received NAC. In total, 2045 articles were screened by two reviewers…

Citation impact

193
total citations
FWCI
41.88
Percentile
100%
References
157
Citations per year

Authors

6

Topics & keywords

Topics
Keywords
  • Breast cancer
  • Medicine
  • Triple-negative breast cancer
  • Oncology
  • Meta-analysis
  • Internal medicine
  • Chemotherapy
  • Neoadjuvant therapy
UN Sustainable Development Goals
  • Good health and well-being
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