A Nonswelling Hydrogel with Regenerable High Wet Tissue Adhesion for Bioelectronics

Reducing the swelling of tissue-adhesive hydrogels is crucial for maintaining stable tissue adhesion and inhibiting tissue inflammation. However, reported strategies for reducing swelling always result in a simultaneous decrease in the tissue adhesive strength of the hydrogel. Furthermore, once the covalent bonds break in the currently reported hydrogels, they cannot be rebuilt, and the hydrogel loses its tissue adhesive ability. In this work, a nonswelling hydrogel (named as "PAACP") possessing regenerable high tissue adhesion is synthesized by copolymerizing and crosslinking poly(vinyl butyral) with acrylic acid, gelatin, and chitosan-grafted N-acetyl-l-cysteine. The tissue adhesive strength of the obtained…

• NN
  National Natural Science Foundation of China

  Awards: 52173237, 51903068
• NS
  Natural Science Foundation of Heilongjiang Province

  Award: YQ2020E001
• FR
  Fundamental Research Funds for the Central Universities

  Award: HIT.OCEF.2022018