articleJournal of the American Chemical SocietyFeb 6, 2023Closed access

Coordination-Driven Self-Assembly Strategy-Activated Cu Single-Atom Nanozymes for Catalytic Tumor-Specific Therapy

JZJie ZhouDXDeting XuGTGan TianQHQian HeXZXiao Zhang

Chinese Academy of Sciences · East China University of Technology · +5 more institutions

PubMed
Indexed incrossrefpubmed

Abstract

How to optimize the enzyme-like catalytic activity of nanozymes to improve their applicability has become a great challenge. Herein, we present an l-cysteine (l-Cys) coordination-driven self-assembly strategy to activate polyvinylpyrrolidone (PVP)-modified Cu single-atom nanozymes MoOx-Cu-Cys (denoted as MCCP SAzymes) aiming at catalytic tumor-specific therapy. The Cu single atom content of MCCP can be rationally modulated to 10.10 wt %, which activates the catalase (CAT)-like activity of MoOx nanoparticles to catalyze the decomposition of H2O2 in acidic microenvironments to increase O2 production. Excitingly, the maximized CAT-like catalytic efficiency of MCCP is 138-fold higher than that of typical MnO2…

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248
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22.56
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100%
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68
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Authors

14

Topics & keywords

Topics
Keywords
  • Chemistry
  • Catalysis
  • Catalase
  • Kinetics
  • Reactive oxygen species
  • Combinatorial chemistry
  • Nanoparticle
  • Enzyme
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