Dissecting the immune suppressive human prostate tumor microenvironment via integrated single-cell and spatial transcriptomic analyses

The treatment of low-risk primary prostate cancer entails active surveillance only, while high-risk disease requires multimodal treatment including surgery, radiation therapy, and hormonal therapy. Recurrence and development of metastatic disease remains a clinical problem, without a clear understanding of what drives immune escape and tumor progression. Here, we comprehensively describe the tumor microenvironment of localized prostate cancer in comparison with adjacent normal samples and healthy controls. Single-cell RNA sequencing and high-resolution spatial transcriptomic analyses reveal tumor context dependent changes in gene expression. Our data indicate that an immune suppressive tumor microenvironment…

• PC
  Prostate Cancer Foundation
• AA
  Andrew and Jaime Sullivan Family Foundation
• C
  Cancerfonden

  Award: 2019-
• NI
  National Institutes of Health

  Awards: P30CA006516, R01HL131768, DK103074
• HS
  Harvard Stem Cell Institute
• NC
  National Cancer Institute

  Award: P30CA006516