A stay of execution: ATF4 regulation and potential outcomes for the integrated stress response
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Abstract
ATF4 is a cellular stress induced bZIP transcription factor that is a hallmark effector of the integrated stress response. The integrated stress response is triggered by phosphorylation of the alpha subunit of the eukaryotic initiation factor 2 complex that can be carried out by the cellular stress responsive kinases; GCN2, PERK, PKR, and HRI. eIF2α phosphorylation downregulates mRNA translation initiation en masse , however ATF4 translation is upregulated. The integrated stress response can output two contradicting outcomes in cells; pro-survival or apoptosis. The mechanism for choice between these outcomes is unknown, however combinations of ATF4 heterodimerisation partners and post-translational…
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Authors
2Topics & keywords
Topics
Keywords
- Integrated stress response
- ATF4
- Phosphorylation
- Translation (biology)
- Cell biology
- Effector
- Eukaryotic translation
- EIF4A1
UN Sustainable Development Goals
- Good health and well-being
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