reviewFrontiers in EndocrinologyFeb 7, 2023GOLD OA

The impact of oxidative stress-induced mitochondrial dysfunction on diabetic microvascular complications

ZZZiwei ZhangQHQingxia HuangDZDaqing ZhaoFLFengmei LianXLXiangyan Li

Changchun University of Chinese Medicine · The Affiliated Hospital to Changchun University of Chinese Medicine · +2 more institutions

Indexed incrossrefdoaj

Abstract

Diabetes mellitus (DM) is a metabolic disease characterized by chronic hyperglycaemia, with absolute insulin deficiency or insulin resistance as the main cause, and causes damage to various target organs including the heart, kidney and neurovascular. In terms of the pathological and physiological mechanisms of DM, oxidative stress is one of the main mechanisms leading to DM and is an important link between DM and its complications. Oxidative stress is a pathological phenomenon resulting from an imbalance between the production of free radicals and the scavenging of antioxidant systems. The main site of reactive oxygen species (ROS) production is the mitochondria, which are also the main organelles damaged. In…

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Topics & keywords

Topics
Keywords
  • Oxidative stress
  • Mitochondrion
  • Reactive oxygen species
  • Oxidative phosphorylation
  • Mitochondrial DNA
  • Insulin resistance
  • Diabetes mellitus
  • Biology
UN Sustainable Development Goals
  • Good health and well-being
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