The gut microbial metabolite trimethylamine N-oxide and cardiovascular diseases

Morbidity and mortality of cardiovascular diseases (CVDs) are exceedingly high worldwide. Researchers have found that the occurrence and development of CVDs are closely related to intestinal microecology. Imbalances in intestinal microecology caused by changes in the composition of the intestinal microbiota will eventually alter intestinal metabolites, thus transforming the host physiological state from healthy mode to pathological mode. Trimethylamine N-oxide (TMAO) is produced from the metabolism of dietary choline and L-carnitine by intestinal microbiota, and many studies have shown that this important product inhibits cholesterol metabolism, induces platelet aggregation and thrombosis, and promotes…

• GO
  Government of Jiangsu Province
• XM
  Xuzhou Medical University

  Award: No.D2020013
• SP
  Shuangchuang Program of Jiangsu Province

  Award: No.JSSCBS20211252
• NS
  Natural Science Research of Jiangsu Higher Education Institutions of China

  Awards: No. 22KJB310021, No.22KJB520040
• NC
  National College Students Innovation and Entrepreneurship Training Program

  Award: No.202110313048Y