Lobar or Sublobar Resection for Peripheral Stage IA Non–Small-Cell Lung Cancer
Memorial Sloan Kettering Cancer Center · NewYork–Presbyterian Hospital · +21 more institutions
Abstract
The increased detection of small-sized peripheral non-small-cell lung cancer (NSCLC) has renewed interest in sublobar resection in lieu of lobectomy.
We conducted a multicenter, noninferiority, phase 3 trial in which patients with NSCLC clinically staged as T1aN0 (tumor size, ≤2 cm) were randomly assigned to undergo sublobar resection or lobar resection after intraoperative confirmation of node-negative disease. The primary end point was disease-free survival, defined as the time between randomization and disease recurrence or death from any cause. Secondary end points were overall survival, locoregional and systemic recurrence, and pulmonary functions.
Citation impact
- FWCI
- 239.26
- Percentile
- 100%
- References
- 19
Authors
21- NKNasser K. AltorkiCorresponding
Memorial Sloan Kettering Cancer Center, NewYork–Presbyterian Hospital, SUNY Upstate Medical University, Cornell University, New York Hospital Queens, Presbyterian Hospital
- XWXiaofei Wang
Memorial Sloan Kettering Cancer Center, Duke University, SUNY Upstate Medical University, Cornell University
- DKDavid Kozono
Memorial Sloan Kettering Cancer Center, SUNY Upstate Medical University, Cornell University, Digital Research Alliance of Canada
- CWColleen Watt
Memorial Sloan Kettering Cancer Center, SUNY Upstate Medical University, Cornell University, Digital Research Alliance of Canada
- RLRodney Landrenau
Memorial Sloan Kettering Cancer Center, SUNY Upstate Medical University, Cornell University, University of Pittsburgh Medical Center
Topics & keywords
- Stage (stratigraphy)
- Peripheral
- Medicine
- Lung cancer
- Resection
- Lung
- Radiology
- Oncology
- Good health and well-being