Immunogenicity of decellularized extracellular matrix scaffolds: a bottleneck in tissue engineering and regenerative medicine
Shahid Beheshti University of Medical Sciences · University of California, Los Angeles · +1 more institution
Abstract
Tissue-engineered decellularized extracellular matrix (ECM) scaffolds hold great potential to address the donor shortage as well as immunologic rejection attributed to cells in conventional tissue/organ transplantation. Decellularization, as the key process in manufacturing ECM scaffolds, removes immunogen cell materials and significantly alleviates the immunogenicity and biocompatibility of derived scaffolds. However, the application of these bioscaffolds still confronts major immunologic challenges. This review discusses the interplay between damage-associated molecular patterns (DAMPs) and antigens as the main inducers of innate and adaptive immunity to aid in manufacturing biocompatible grafts with…
Citation impact
- FWCI
- 79.17
- Percentile
- 100%
- References
- 234
Authors
8- MKMohammadreza KasraviCorresponding
Shahid Beheshti University of Medical Sciences
- AAArmin Ahmadi
Shahid Beheshti University of Medical Sciences
- ABAmirhesam Babajani
Shahid Beheshti University of Medical Sciences
- RMRadman Mazloomnejad
Shahid Beheshti University of Medical Sciences
- MRMohammad Reza Hatamnejad
Shahid Beheshti University of Medical Sciences
Topics & keywords
- Decellularization
- Immunogenicity
- Extracellular matrix
- Tissue engineering
- Regenerative medicine
- Antigen
- Biocompatibility
- Immunogen