Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial

Waziry, Reem; Ryan, Calen P.; Corcoran, David L.; Huffman, K. M.; Kobor, Michael S.; Kothari, Meeraj; Graf, Gloria Huei-Jong; Kraus, Virginia B.; Kraus, William E.; Lin, David; Pieper, Carl F.; Ramaker, M. E.; Bhapkar, Manjushri; Das, Shilpa; Ferrucci, Luigi; Hastings, W. J.; Kebbe, Maryam; Parker, Daniel; Racette, Susan B.; Shalev, Idan; Schilling, Birgit; Belsky, Daniel W.

doi:10.1038/s43587-022-00357-y

articleNature AgingFeb 9, 2023HYBRID OA

Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial

RWReem Waziry CPCalen P. Ryan DLDavid L. Corcoran KMK. M. Huffman MSMichael S. Kobor

Columbia University · University of North Carolina at Chapel Hill · +12 more institutions

PubMed

Indexed incrossrefpubmed

Abstract

Abstract The geroscience hypothesis proposes that therapy to slow or reverse molecular changes that occur with aging can delay or prevent multiple chronic diseases and extend healthy lifespan 1–3 . Caloric restriction (CR), defined as lessening caloric intake without depriving essential nutrients 4 , results in changes in molecular processes that have been associated with aging, including DNA methylation (DNAm) 5–7 , and is established to increase healthy lifespan in multiple species 8,9 . Here we report the results of a post hoc analysis of the influence of CR on DNAm measures of aging in blood samples from the Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy (CALERIE) trial, a…

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Topics & keywords

Topics

Keywords

dNaM
Caloric theory
Calorie restriction
Randomized controlled trial
Healthy aging
Medicine
Population
Longevity

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