Surface-functionalized design of blood-contacting biomaterials for preventing coagulation and promoting hemostasis

Abstract The anticoagulation and hemostatic properties of blood-contacting materials are opposite lines of research, but their realization mechanisms are inspired by each other. Contact between blood and implantable biomaterials is a classic problem in tribological research, as both antithrombotic and hemostatic materials are closely associated with this problem. Thrombus formation on the surfaces of blood-contacting biomedical devices can detrimentally affect their performance and patient life, so specific surface functionalization is required. Currently, intensive research has focused on the development of super-lubricated or super-hydrophobic coatings, as well as coatings that deliver antithrombotic drugs.…

• NN
  National Natural Science Foundation of China

  Award: 52022043
• NS
  Natural Science Foundation of Hebei Province

  Award: H2021201005
• TU
  Tsinghua University
• SK
  State Key Laboratory of Mechanical System and Vibration

  Award: MSV202209