articleSignal Transduction and Targeted TherapyFeb 13, 2023GOLD OA

MiR146a-loaded engineered exosomes released from silk fibroin patch promote diabetic wound healing by targeting IRAK1

QLQiankun LiWHWenzhi HuQHQilin HuangJYJie YangBLBingmin Li

Chinese PLA General Hospital · Chinese Academy of Medical Sciences & Peking Union Medical College · +4 more institutions

PubMed
Indexed incrossrefdoajpubmed

Abstract

Unhealable diabetic wounds need to be addressed with the help of newer, more efficacious strategies. Exosomes combined with biomaterials for sustained delivery of therapeutic agents are expected to bring new hope for chronic wound treatment. Here, the engineered exosomes modified for efficiently loading miR146a and attaching to silk fibroin patch (SFP) were demonstrated to promote diabetic wound healing. Silk fibroin binding peptide (SFBP) was screened through phage display, and SFBP-Gluc-MS2 (SGM) and pac-miR146a-pac fusion protein were constructed. The designed exosomes (SGM-Exos, miR146a-Exos, and SGM-miR146a-Exos) were isolated from the engineered placental mesenchymal stem cells (PMSCs) transduced with…

Citation impact

173
total citations
FWCI
25.06
Percentile
100%
References
39
Citations per year

Authors

15

Topics & keywords

Topics
Keywords
  • Fibroin
  • Microvesicles
  • Wound healing
  • Mesenchymal stem cell
  • Cancer research
  • Regenerative medicine
  • Medicine
  • Cell biology
UN Sustainable Development Goals
  • Good health and well-being
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