An elusive consensus definition of sarcopenia impedes research and clinical treatment: A narrative review

The definition of sarcopenia, the age-related loss of muscle mass, has evolved since the term's inception and yet there is no consensus. Many of the identified definitions of sarcopenia centre their criteria around the loss of muscle mass, loss of function, and weakness. Common variables to various definitions of sarcopenia are appendicular lean soft tissue mass (often called muscle mass), grip strength, and gait speed. However, a lack of consensus remains among operational definitions and diagnostics for this newly recognized disease and may be attributed to the absence of appropriate tools that accurately measure the outcomes of interest, such as skeletal muscle instead of lean mass. In this narrative…

• CR
  Canada Research Chairs
• CI
  Canadian Institutes of Health Research
• MI
  McMaster Institute for Research on Aging, McMaster University
• NS
  Natural Sciences and Engineering Research Council of Canada