articleJournal of the American Chemical SocietyFeb 13, 2023Closed access

Supramolecular Photosensitizer Enables Oxygen-Independent Generation of Hydroxyl Radicals for Photodynamic Therapy

KTKun‐Xu TengLNLi‐Ya NiuQYQing‐Zheng Yang

Beijing Normal University

PubMed
Indexed incrossrefpubmed

Abstract

The highly oxygen-dependent nature of photodynamic therapy (PDT) limits its therapeutic efficacy against hypoxic solid tumors in clinics, which is an urgent problem to be solved. Herein, we develop an oxygen-independent supramolecular photodynamic agent that produces hydroxyl radical (•OH) by oxidizing water in the presence of intracellularly abundant pyruvic acid under oxygen-free conditions. A fluorene-substituted BODIPY was designed as the electron donor and coassembled with perylene diimide as the electron acceptor to form the quadruple hydrogen-bonded supramolecular photodynamic agent. Detailed mechanism studies reveal that intermolecular electron transfer and charge separation upon light irradiation…

Citation impact

362
total citations
FWCI
37.73
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100%
References
46
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Authors

3

Topics & keywords

Topics
Keywords
  • Chemistry
  • Photodynamic therapy
  • Photochemistry
  • Photosensitizer
  • Radical
  • Perylene
  • Singlet oxygen
  • Oxygen
UN Sustainable Development Goals
  • Clean water and sanitation
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