articleAmerican Journal of Medical Genetics Part AFeb 13, 2023HYBRID OA

Nosology of genetic skeletal disorders: 2023 revision

University of Lausanne · National Institutes of Health · +33 more institutions

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Abstract

The "Nosology of genetic skeletal disorders" has undergone its 11th revision and now contains 771 entries associated with 552 genes reflecting advances in molecular delineation of new disorders thanks to advances in DNA sequencing technology. The most significant change as compared to previous versions is the adoption of the dyadic naming system, systematically associating a phenotypic entity with the gene it arises from. We consider this a significant step forward as dyadic naming is more informative and less prone to errors than the traditional use of list numberings and eponyms. Despite the adoption of dyadic naming, efforts have been made to maintain strong ties to the MIM catalog and its historical data.…

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