Oxidative Stress in Depression: The Link with the Stress Response, Neuroinflammation, Serotonin, Neurogenesis and Synaptic Plasticity

Correia, Ana Salomé; Cardoso, Armando; Vale, Nuno

doi:10.3390/antiox12020470

reviewAntioxidantsFeb 13, 2023GOLD OA

Oxidative Stress in Depression: The Link with the Stress Response, Neuroinflammation, Serotonin, Neurogenesis and Synaptic Plasticity

ASAna Salomé Correia ACArmando Cardoso NVNuno Vale

Universidade do Porto · Centre for Health Technology and Services Research

PubMed

Indexed incrossrefdoajpubmed

Abstract

Depression is a prevalent, complex, and highly debilitating disease. The full comprehension of this disease is still a global challenge. Indeed, relapse, recurrency, and therapeutic resistance are serious challenges in the fight against depression. Nevertheless, abnormal functioning of the stress response, inflammatory processes, neurotransmission, neurogenesis, and synaptic plasticity are known to underlie the pathophysiology of this mental disorder. The role of oxidative stress in disease and, particularly, in depression is widely recognized, being important for both its onset and development. Indeed, excessive generation of reactive oxygen species and lack of efficient antioxidant response trigger processes…

Citation impact

299

total citations

FWCI: 28.06
Percentile: 100%
References: 131

Citations per year

Authors

3

Topics & keywords

Topics

Keywords

Neurogenesis
Neuroinflammation
Neuroscience
Neurodegeneration
Oxidative stress
Serotonergic
Synaptic plasticity
Psychology

UN Sustainable Development Goals

Good health and well-being

No related works found for this paper.