Molecular pathways that drive diabetic kidney disease
Institute of Nutrition, Metabolism and Diabetes · University of Pennsylvania
Abstract
Kidney disease is a major driver of mortality among patients with diabetes and diabetic kidney disease (DKD) is responsible for close to half of all chronic kidney disease cases. DKD usually develops in a genetically susceptible individual as a result of poor metabolic (glycemic) control. Molecular and genetic studies indicate the key role of podocytes and endothelial cells in driving albuminuria and early kidney disease in diabetes. Proximal tubule changes show a strong association with the glomerular filtration rate. Hyperglycemia represents a key cellular stress in the kidney by altering cellular metabolism in endothelial cells and podocytes and by imposing an excess workload requiring energy and oxygen for…
Citation impact
- FWCI
- 55.41
- Percentile
- 100%
- References
- 180
Authors
6- SMSamer MohandesCorresponding
Institute of Nutrition, Metabolism and Diabetes, University of Pennsylvania
- TDTomohito Doke
Institute of Nutrition, Metabolism and Diabetes, University of Pennsylvania
- HHHailong Hu
Institute of Nutrition, Metabolism and Diabetes, University of Pennsylvania
- DMDhanunjay Mukhi
Institute of Nutrition, Metabolism and Diabetes, University of Pennsylvania
- PDPoonam Dhillon
Institute of Nutrition, Metabolism and Diabetes, University of Pennsylvania
Topics & keywords
- Kidney
- Albuminuria
- Kidney disease
- Endocrinology
- Diabetes mellitus
- Podocyte
- Internal medicine
- Oxidative stress
- Good health and well-being