Alzheimer’s Disease: An Updated Overview of Its Genetics

Alzheimer’s disease (AD) is the most common neurodegenerative disease in the world. It is classified as familial and sporadic. The dominant familial or autosomal presentation represents 1–5% of the total number of cases. It is categorized as early onset (EOAD; <65 years of age) and presents genetic mutations in presenilin 1 (PSEN1), presenilin 2 (PSEN2), or the Amyloid precursor protein (APP). Sporadic AD represents 95% of the cases and is categorized as late-onset (LOAD), occurring in patients older than 65 years of age. Several risk factors have been identified in sporadic AD; aging is the main one. Nonetheless, multiple genes have been associated with the different neuropathological events involved in…

• MD
  Ministerio de Educación Superior, Ciencia y Tecnología, República Dominicana

  Awards: IA205423, IN206322, 319578, 319433, 2018-2019-2A3-208, IA202021
• CN
  Consejo Nacional de Ciencia y Tecnología

  Awards: 319433, 319433 and 319578