reviewInternational Journal of Molecular SciencesFeb 16, 2023GOLD OA

Crosstalk of Inflammatory Cytokines within the Breast Tumor Microenvironment

OHOla HabanjarRBRea BingulaCDCaroline DecombatMDMona Diab‐AssafFCFlorence Caldefie‐Chezet

Université Clermont Auvergne · Unité de Nutrition Humaine · +3 more institutions

PubMed
Indexed incrossrefpubmed

Abstract

Several immune and immunocompetent cells, including dendritic cells, macrophages, adipocytes, natural killer cells, T cells, and B cells, are significantly correlated with the complex discipline of oncology. Cytotoxic innate and adaptive immune cells can block tumor proliferation, and others can prevent the immune system from rejecting malignant cells and provide a favorable environment for tumor progression. These cells communicate with the microenvironment through cytokines, a chemical messenger, in an endocrine, paracrine, or autocrine manner. These cytokines play an important role in health and disease, particularly in host immune responses to infection and inflammation. They include chemokines,…

Citation impact

240
total citations
FWCI
52.07
Percentile
100%
References
452
Citations per year

Authors

6

Topics & keywords

Topics
Keywords
  • Crosstalk
  • Tumor microenvironment
  • Breast tumor
  • Cancer research
  • Inflammation
  • Inflammatory breast cancer
  • Medicine
  • Proinflammatory cytokine
UN Sustainable Development Goals
  • Good health and well-being
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