reviewCellsFeb 18, 2023GOLD OA

Mechanisms of Blood–Brain Barrier Protection by Microbiota-Derived Short-Chain Fatty Acids

EFEkaterina FockPRParnova Rg

Institute of Evolutionary Physiology and Biochemistry

PubMed
Indexed incrossrefdoajpubmed

Abstract

Impairment of the blood-brain barrier (BBB) integrity is implicated in the numerous neurological disorders associated with neuroinflammation, neurodegeneration and aging. It is now evident that short-chain fatty acids (SCFAs), mainly acetate, butyrate and propionate, produced by anaerobic bacterial fermentation of the dietary fiber in the intestine, have a key role in the communication between the gastrointestinal tract and nervous system and are critically important for the preservation of the BBB integrity under different pathological conditions. The effect of SCFAs on the improvement of the compromised BBB is mainly based on the decrease in paracellular permeability via restoration of junctional complex…

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310
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Authors

2

Topics & keywords

Topics
Keywords
  • Blood–brain barrier
  • Neuroinflammation
  • Cell biology
  • Butyrate
  • Biology
  • Histone
  • Neurodegeneration
  • Crosstalk
UN Sustainable Development Goals
  • Life in Land
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