Flowerbed-Inspired Biomimetic Scaffold with Rapid Internal Tissue Infiltration and Vascularization Capacity for Bone Repair

Zhou, Xiaojun; Qian, Yuhan; Chen, Liang; Li, Tao; Sun, Xin; Ma, Xiaojun; Wang, Jinwu; He, Chuanglong

doi:10.1021/acsnano.3c00598

articleACS NanoFeb 21, 2023Closed access

Flowerbed-Inspired Biomimetic Scaffold with Rapid Internal Tissue Infiltration and Vascularization Capacity for Bone Repair

XZXiaojun Zhou YQYuhan Qian LCLiang Chen TLTao Li XSXin Sun

Donghua University · State Key Laboratory for Modification of Chemical Fibers and Polymer Materials · +7 more institutions

PubMed

Indexed incrossrefpubmed

Abstract

The favorable microstructure and bioactivity of tissue-engineered bone scaffolds are closely associated with the regenerative efficacy of bone defects. For the treatment of large bone defects, however, most of them fail to meet requirements such as adequate mechanical strength, highly porous structure, and excellent angiogenic and osteogenic activities. Herein, inspired by the characteristics of a “flowerbed”, we construct a short nanofiber aggregates-enriched dual-factor delivery scaffold via 3D printing and electrospinning techniques for guiding vascularized bone regeneration. By the assembly of short nanofibers containing dimethyloxalylglycine (DMOG)-loaded mesoporous silica nanoparticles with a 3D printed…

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FWCI: 20.17
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Authors

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Topics & keywords

Topics

Keywords

Scaffold
Nanofiber
Materials science
Biomedical engineering
Electrospinning
Bone healing
Regeneration (biology)
Polycaprolactone

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