articleProceedings of the National Academy of SciencesFeb 21, 2023GREEN OA

Epigenetic-based age acceleration in a representative sample of older Americans: Associations with aging-related morbidity and mortality

JDJessica D. FaulJKJung Ki KimMEMorgan E. LevineBTBharat ThyagarajanDRDavid R. Weir

University of Michigan · University of Southern California · +2 more institutions

PubMed
Indexed incrossrefpubmed

Abstract

Biomarkers developed from DNA methylation (DNAm) data are of growing interest as predictors of health outcomes and mortality in older populations. However, it is unknown how epigenetic aging fits within the context of known socioeconomic and behavioral associations with aging-related health outcomes in a large, population-based, and diverse sample. This study uses data from a representative, panel study of US older adults to examine the relationship between DNAm-based age acceleration measures in the prediction of cross-sectional and longitudinal health outcomes and mortality. We examine whether recent improvements to these scores, using principal component (PC)-based measures designed to remove some of the…

Citation impact

200
total citations
FWCI
29.36
Percentile
100%
References
41
Citations per year

Authors

6

Topics & keywords

Topics
Keywords
  • dNaM
  • Socioeconomic status
  • Medicine
  • Gerontology
  • Context (archaeology)
  • Health and Retirement Study
  • Demography
  • Population
UN Sustainable Development Goals
  • Good health and well-being
No related works found for this paper.

Funding