Role of tumor microenvironment in cancer progression and therapeutic strategy
Zhejiang Shuren University · First Affiliated Hospital Zhejiang University · +4 more institutions
Abstract
Cancer is now considered a tumor microenvironment (TME) disease, although it was originally thought to be a cell and gene expression disorder. Over the past 20 years, significant advances have been made in understanding the complexity of the TME and its impact on responses to various anticancer therapies, including immunotherapies. Cancer immunotherapy can recognize and kill cancer cells by regulating the body's immune system. It has achieved good therapeutic effects in various solid tumors and hematological malignancies. Recently, blocking of programmed death-1 (PD-1), programmed death-1 ligand-1 (PD-L1), and programmed death Ligand-2 (PD-L2), the construction of antigen chimeric T cells (CAR-T) and tumor…
Citation impact
- FWCI
- 88.75
- Percentile
- 100%
- References
- 158
Authors
9- QWQingjing Wang
Zhejiang Shuren University
- XSXueting Shao
First Affiliated Hospital Zhejiang University, Zhejiang University
- YZYuxuan Zhang
Zhejiang Shuren University
- MZMiaojin Zhu
State Key Laboratory of Diagnosis and Treatment of Infectious Diseases, Zhejiang University
- FXFrederick X.C. Wang
Methodist Hospital, Texas A&M University
Topics & keywords
- Cancer
- Tumor microenvironment
- Tumor progression
- Cancer research
- Medicine
- Oncology
- Internal medicine
- Good health and well-being