articleNatureFeb 22, 2023HYBRID OA

Microbiota-derived 3-IAA influences chemotherapy efficacy in pancreatic cancer

JTJoseph TintelnotYXYang XuTRTill Robin LeskerMSMartin SchönleinLKLeonie Konczalla

Universität Hamburg · University Medical Center Hamburg-Eppendorf · +12 more institutions

PubMed
Indexed incrossrefpubmed

Abstract

Abstract Pancreatic ductal adenocarcinoma (PDAC) is expected to be the second most deadly cancer by 2040, owing to the high incidence of metastatic disease and limited responses to treatment 1,2 . Less than half of all patients respond to the primary treatment for PDAC, chemotherapy 3,4 , and genetic alterations alone cannot explain this 5 . Diet is an environmental factor that can influence the response to therapies, but its role in PDAC is unclear. Here, using shotgun metagenomic sequencing and metabolomic screening, we show that the microbiota-derived tryptophan metabolite indole-3-acetic acid (3-IAA) is enriched in patients who respond to treatment. Faecal microbiota transplantation, short-term dietary…

Citation impact

444
total citations
FWCI
69.65
Percentile
100%
References
51
Citations per year

Authors

31

Topics & keywords

Topics
Keywords
  • Cancer research
  • Pancreatic cancer
  • Cancer
  • Gut flora
  • Biology
  • Metabolite
  • Downregulation and upregulation
  • Chemotherapy
UN Sustainable Development Goals
  • Zero hunger
No related works found for this paper.

Funding