FUNDC1 interacts with GPx4 to govern hepatic ferroptosis and fibrotic injury through a mitophagy-dependent manner
Fudan University · National Clinical Research Center for Digestive Diseases · +9 more institutions
Abstract
Liver fibrosis is a life-threatening pathological anomaly which usually evolves into advanced liver cirrhosis and hepatocellular carcinoma although limited therapeutic option is readily available. FUN14 domain containing 1 (FUNDC1) is a mitophagy receptor with little information in liver fibrosis.
This study was designed to examine the role for FUNDC1 in carbon tetrachloride (CCl4)-induced liver injury.
Citation impact
- FWCI
- 44.66
- Percentile
- 100%
- References
- 61
Authors
11- YBYaguang Bi
Fudan University, National Clinical Research Center for Digestive Diseases, Zhongshan Hospital
- SLShuolin Liu
Fudan University, National Clinical Research Center for Digestive Diseases, Zhongshan Hospital
- XQXing Qin
Xijing Hospital, Air Force Medical University
- MAMiyesaier Abudureyimu
Fudan University, Shanghai Xuhui Central Hospital
- LWLu Wang
Air Force Engineering University, Xijing Hospital, Air Force Medical University
Topics & keywords
- Mitophagy
- Mitochondrion
- GPX4
- Cell biology
- Liver injury
- Hepatocyte
- Cancer research
- Chemistry