A Whole‐Course‐Repair System Based on Neurogenesis‐Angiogenesis Crosstalk and Macrophage Reprogramming Promotes Diabetic Wound Healing

Abstract Diabetic wound (DW) therapy is currently a big challenge in medicine and strategies to enhance neurogenesis and angiogenesis have appeared to be a promising direction. However, the current treatments have failed to coordinate neurogenesis and angiogenesis simultaneously, leading to an increased disability rate caused by DWs. Herein, a whole‐course‐repair system is introduced by a hydrogel to concurrently achieve a mutually supportive cycle of neurogenesis‐angiogenesis under a favorable immune‐microenvironment. This hydrogel can first be one‐step packaged in a syringe for later in situ local injections to cover wounds long‐termly for accelerated wound healing via the synergistic effect of magnesium…

• NS
  National Science Foundation
• RG
  Rijksuniversiteit Groningen
• NN
  National Natural Science Foundation of China

  Awards: 31900963, 82202714, 82002313, 2021TQ0118, 82072444, No. 82202714, 2020kqhm008, 2021kqhm002, No. 82002313, No. 82072444
• CP
  China Postdoctoral Science Foundation

  Awards: 82002313, 2021TQ0118, 82072444, 2020kqhm008
• HU
  Huazhong University of Science and Technology

  Award: 82072444
• TU
  Tongji University
• TM
  Tongji Medical College, Huazhong University of Science and Technology