JAK/STAT pathway: Extracellular signals, diseases, immunity, and therapeutic regimens
Central South University · Wenzhou Medical University · +8 more institutions
Abstract
Janus kinase/signal transduction and transcription activation (JAK/STAT) pathways were originally thought to be intracellular signaling pathways that mediate cytokine signals in mammals. Existing studies show that the JAK/STAT pathway regulates the downstream signaling of numerous membrane proteins such as such as G-protein-associated receptors, integrins and so on. Mounting evidence shows that the JAK/STAT pathways play an important role in human disease pathology and pharmacological mechanism. The JAK/STAT pathways are related to aspects of all aspects of the immune system function, such as fighting infection, maintaining immune tolerance, strengthening barrier function, and cancer prevention, which are all…
Citation impact
- FWCI
- 61.66
- Percentile
- 100%
- References
- 280
Authors
9- QHQian Hu
Central South University, Wenzhou Medical University, Sir Run Run Shaw Hospital, PharmacoGenetics (China), Xiangya Hospital Central South University, Zhejiang University
- QBQihui Bian
Wenzhou Medical University
- DRDing‐Chao Rong
Third Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University
- LWLei‐Yun Wang
Central South University, Wuhan Third Hospital, PharmacoGenetics (China), Xiangya Hospital Central South University
- JSJianan Song
Wenzhou Medical University
Topics & keywords
- JAK-STAT signaling pathway
- stat
- Janus kinase
- Signal transduction
- Biology
- Immune system
- Cell biology
- Mediator
- Good health and well-being