A Brief Introduction to Chemical Reaction Optimization
University of Cambridge · GW Pharmaceuticals (United Kingdom) · +3 more institutions
Abstract
From the start of a synthetic chemist's training, experiments are conducted based on recipes from textbooks and manuscripts that achieve clean reaction outcomes, allowing the scientist to develop practical skills and some chemical intuition. This procedure is often kept long into a researcher's career, as new recipes are developed based on similar reaction protocols, and intuition-guided deviations are conducted through learning from failed experiments. However, when attempting to understand chemical systems of interest, it has been shown that model-based, algorithm-based, and miniaturized high-throughput techniques outperform human chemical intuition and achieve reaction optimization in a much more time- and…
Citation impact
- FWCI
- 41.22
- Percentile
- 100%
- References
- 336
Authors
9- CJConnor J. TaylorCorresponding
University of Cambridge, GW Pharmaceuticals (United Kingdom)
- APAlexander Pomberger
University of Cambridge
- KFKobi Felton
University of Cambridge
- RGRachel Grainger
GW Pharmaceuticals (United Kingdom)
- MHMagda H. Barecka
Northeastern University, The Cambridge Centre for Advanced Research and Education in Singapore
Topics & keywords
- Intuition
- Chemistry
- Biochemical engineering
- Computer science
- Management science
- Nanotechnology
- Cognitive science
- Psychology
- Quality Education