articleCancer CellFeb 23, 2023HYBRID OA

Intratumoral CD8+ T cells with a tissue-resident memory phenotype mediate local immunity and immune checkpoint responses in breast cancer

BVBalaji VirassamyFCFranco CaramiaPSPeter SavasSSSneha SantJWJianan Wang

Peter MacCallum Cancer Centre · Walter and Eliza Hall Institute of Medical Research · +5 more institutions

PubMed
Indexed incrossrefpubmed

Abstract

Gene signature extracted from tumor-free tissue was significantly associated with improved clinical outcomes in TNBC patients treated with checkpoint inhibitors.

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215
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Authors

26

Topics & keywords

Topics
Keywords
  • Cytotoxic T cell
  • CD8
  • Immune checkpoint
  • Immune system
  • Cancer research
  • Biology
  • Phenotype
  • Breast cancer
UN Sustainable Development Goals
  • Good health and well-being
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