articleNature MedicineFeb 27, 2023GOLD OA

The artificial sweetener erythritol and cardiovascular event risk

MWMarco WitkowskiINIna NemetHSHassan S. AlamriJWJennifer WilcoxNGNilaksh Gupta

Cleveland Clinic Lerner College of Medicine · King Saud bin Abdulaziz University for Health Sciences · +9 more institutions

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Abstract

Artificial sweeteners are widely used sugar substitutes, but little is known about their long-term effects on cardiometabolic disease risks. Here we examined the commonly used sugar substitute erythritol and atherothrombotic disease risk. In initial untargeted metabolomics studies in patients undergoing cardiac risk assessment (n = 1,157; discovery cohort, NCT00590200 ), circulating levels of multiple polyol sweeteners, especially erythritol, were associated with incident (3 year) risk for major adverse cardiovascular events (MACE; includes death or nonfatal myocardial infarction or stroke). Subsequent targeted metabolomics analyses in independent US (n = 2,149, NCT00590200 ) and European (n = 833,…

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203
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31.99
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100%
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Authors

18

Topics & keywords

Topics
Keywords
  • Erythritol
  • Artificial Sweetener
  • Cardiovascular event
  • Medicine
  • Event (particle physics)
  • Sweetening agents
  • Intensive care medicine
  • Food science
UN Sustainable Development Goals
  • Good health and well-being
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