Managing the immune microenvironment of osteosarcoma: the outlook for osteosarcoma treatment
Sichuan University · State Key Laboratory of Biotherapy · +4 more institutions
Abstract
Osteosarcoma, with poor survival after metastasis, is considered the most common primary bone cancer in adolescents. Notwithstanding the efforts of researchers, its five-year survival rate has only shown limited improvement, suggesting that existing therapeutic strategies are insufficient to meet clinical needs. Notably, immunotherapy has shown certain advantages over traditional tumor treatments in inhibiting metastasis. Therefore, managing the immune microenvironment in osteosarcoma can provide novel and valuable insight into the multifaceted mechanisms underlying the heterogeneity and progression of the disease. Additionally, given the advances in nanomedicine, there exist many advanced nanoplatforms for…
Citation impact
- FWCI
- 31.63
- Percentile
- 100%
- References
- 510
Authors
7- HTHailong Tian
Sichuan University, State Key Laboratory of Biotherapy
- JCJiangjun Cao
Sichuan University, State Key Laboratory of Biotherapy
- BLBowen Li
Sichuan University, State Key Laboratory of Biotherapy
- ECEdouard C. Nice
Monash University
- HMHaijiao MaoCorresponding
Ningbo University, Ningbo University Affiliated Hospital
Topics & keywords
- Osteosarcoma
- Immunotherapy
- Nanomedicine
- Medicine
- Tumor microenvironment
- Immune system
- Metastasis
- Cancer research
- Good health and well-being
Funding
- NNNational Natural Science Foundation of ChinaAwards: No. 81821002, ZYJC21004, ZYGD22007, 81821002, 82130082
- SUSichuan UniversityAwards: 82130082, ZYGD22007, ZYJC21004
- NSNatural Science Foundation of Henan ProvinceAward: 222300420072
- YSYoung Scientists Fund
- WCWest China Hospital, Sichuan UniversityAwards: ZYJC21004, ZYJC21004 and ZYGD22007, ZYGD22007, 1.3.5 project, 1.3.5
- BABasic and Applied Basic Research Foundation of Guangdong ProvinceAwards: No. 2019B030302012, 2019B030302012