Targeting p53 pathways: mechanisms, structures and advances in therapy

The TP53 tumor suppressor is the most frequently altered gene in human cancers, and has been a major focus of oncology research. The p53 protein is a transcription factor that can activate the expression of multiple target genes and plays critical roles in regulating cell cycle, apoptosis, and genomic stability, and is widely regarded as the "guardian of the genome". Accumulating evidence has shown that p53 also regulates cell metabolism, ferroptosis, tumor microenvironment, autophagy and so on, all of which contribute to tumor suppression. Mutations in TP53 not only impair its tumor suppressor function, but also confer oncogenic properties to p53 mutants. Since p53 is mutated and inactivated in most malignant…

• NN
  National Natural Science Foundation of China

  Awards: 81974074, 81570537, 82172654, 82273496, 31900880
• HP
  Hunan Provincial Science and Technology Department

  Awards: 2021RC4012, 2018RS3026
• CS
  Central South University