reviewMolecular CancerMar 2, 2023GOLD OA

New frontiers in immune checkpoint B7-H3 (CD276) research and drug development

AAAyechew Adera GetuATAbiye TigabuMZMing ZhouJLJianrong LuØFØystein Fodstad

China Medical University · University of Gondar · +3 more institutions

PubMed
Indexed incrossrefdoajpubmed

Abstract

B7-H3 (CD276), a member of the B7 family of proteins, is a key player in cancer progression. This immune checkpoint molecule is selectively expressed in both tumor cells and immune cells within the tumor microenvironment. In addition to its immune checkpoint function, B7-H3 has been linked to tumor cell proliferation, metastasis, and therapeutic resistance. Furthermore, its drastic difference in protein expression levels between normal and tumor tissues suggests that targeting B7-H3 with drugs would lead to cancer-specific toxicity, minimizing harm to healthy cells. These properties make B7-H3 a promising target for cancer therapy.Recently, important advances in B7-H3 research and drug development have been…

Citation impact

211
total citations
FWCI
45.81
Percentile
100%
References
148
Citations per year

Authors

6

Topics & keywords

Topics
Keywords
  • Biology
  • Immune system
  • Immune checkpoint
  • Tumor microenvironment
  • Cancer research
  • Metastasis
  • Cancer
  • Cancer cell
UN Sustainable Development Goals
  • Good health and well-being
No related works found for this paper.

Funding