CD39/CD73/A2AR pathway and cancer immunotherapy
Foshan Maternity and Child Health Care Hospital · Southern Medical University · +3 more institutions
Abstract
Cancer development is closely associated with immunosuppressive tumor microenvironment (TME) that attenuates antitumor immune responses and promotes tumor cell immunologic escape. The sequential conversion of extracellular ATP into adenosine by two important cell-surface ectonucleosidases CD39 and CD73 play critical roles in reshaping an immunosuppressive TME. The accumulated extracellular adenosine mediates its regulatory functions by binding to one of four adenosine receptors (A1R, A2AR, A2BR and A3R). The A2AR elicits its profound immunosuppressive function via regulating cAMP signaling. The increasing evidence suggests that CD39, CD73 and A2AR could be used as novel therapeutic targets for manipulating the…
Citation impact
- FWCI
- 79.51
- Percentile
- 100%
- References
- 144
Authors
4- CXChenglai XiaCorresponding
Foshan Maternity and Child Health Care Hospital, Southern Medical University
- SYShuanghong Yin
Sun Yat-sen University, Foshan Maternity and Child Health Care Hospital, Sun Yat-sen University Cancer Center, Southern Medical University
- KKKenneth K.W. To
Chinese University of Hong Kong
- LFLiwu Fu
Sun Yat-sen University, Sun Yat-sen University Cancer Center
Topics & keywords
- Adenosinergic
- Tumor microenvironment
- Immunotherapy
- Biology
- Adenosine
- Cancer immunotherapy
- Cancer research
- Cancer
- Good health and well-being