Epigenetic regulation in metabolic diseases: mechanisms and advances in clinical study
Central South University · Second Xiangya Hospital of Central South University
Abstract
Epigenetics regulates gene expression and has been confirmed to play a critical role in a variety of metabolic diseases, such as diabetes, obesity, non-alcoholic fatty liver disease (NAFLD), osteoporosis, gout, hyperthyroidism, hypothyroidism and others. The term 'epigenetics' was firstly proposed in 1942 and with the development of technologies, the exploration of epigenetics has made great progresses. There are four main epigenetic mechanisms, including DNA methylation, histone modification, chromatin remodelling, and noncoding RNA (ncRNA), which exert different effects on metabolic diseases. Genetic and non-genetic factors, including ageing, diet, and exercise, interact with epigenetics and jointly affect…
Citation impact
- FWCI
- 61.50
- Percentile
- 100%
- References
- 438
Authors
10- YWYanlin WuCorresponding
Central South University, Second Xiangya Hospital of Central South University
- ZLZhengjun Lin
Central South University, Second Xiangya Hospital of Central South University
- CLChangchun Li
Central South University, Second Xiangya Hospital of Central South University
- XLXiao Lin
Central South University, Second Xiangya Hospital of Central South University
- SSSu‐Kang Shan
Central South University, Second Xiangya Hospital of Central South University
Topics & keywords
- Epigenetics
- Biology
- DNA methylation
- Bioinformatics
- Computational biology
- Chromatin
- Histone
- microRNA
- Good health and well-being