articleBrainMar 1, 2023HYBRID OA

Potential drug targets for multiple sclerosis identified through Mendelian randomization analysis

JLJianfeng LinJZJiawei ZhouYXYan Xu

Chinese Academy of Medical Sciences & Peking Union Medical College · Peking Union Medical College Hospital

PubMed
Indexed incrossrefpubmed

Abstract

Multiple sclerosis is a complex autoimmune disease, and several therapies for multiple sclerosis have been developed and widely used. However, existing medications for multiple sclerosis were far from satisfactory due to their failure to suppress relapses and alleviate disease progression. Novel drug targets for multiple sclerosis prevention are still needed. We performed Mendelian randomization to explore potential drug targets for multiple sclerosis using summary statistics from the International Multiple Sclerosis Genetics Consortium (nCase = 47 429, nControl = 68 374) and further replicated in UK Biobank (nCase = 1356, nControl = 395 209) and FinnGen cohorts (nCase = 1326, nControl = 359 815). Genetic…

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Authors

3

Topics & keywords

Topics
Keywords
  • Mendelian randomization
  • Multiple sclerosis
  • Mendelian inheritance
  • Natalizumab
  • Odds ratio
  • Medicine
  • Multiple comparisons problem
  • Disease
UN Sustainable Development Goals
  • Good health and well-being
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