CD36+ cancer-associated fibroblasts provide immunosuppressive microenvironment for hepatocellular carcinoma via secretion of macrophage migration inhibitory factor
Ministry of Education of the People's Republic of China · Chinese Academy of Medical Sciences & Peking Union Medical College · +8 more institutions
Abstract
Abstract Hepatocellular carcinoma (HCC) is an immunotherapy-resistant malignancy characterized by high cellular heterogeneity. The diversity of cell types and the interplay between tumor and non-tumor cells remain to be clarified. Single cell RNA sequencing of human and mouse HCC tumors revealed heterogeneity of cancer-associated fibroblast (CAF). Cross-species analysis determined the prominent CD36 + CAFs exhibited high-level lipid metabolism and expression of macrophage migration inhibitory factor (MIF). Lineage-tracing assays showed CD36 + CAFs were derived from hepatic stellate cells. Furthermore, CD36 mediated oxidized LDL uptake-dependent MIF expression via lipid peroxidation/p38/CEBPs axis in CD36 +…
Citation impact
- FWCI
- 48.77
- Percentile
- 100%
- References
- 56
Authors
20- GZGuiqi ZhuCorresponding
Ministry of Education of the People's Republic of China, Chinese Academy of Medical Sciences & Peking Union Medical College, Fudan University, Cancer Institute (WIA), Zhongshan Hospital
- ZTZheng Tang
Ministry of Education of the People's Republic of China, Chinese Academy of Medical Sciences & Peking Union Medical College, Fudan University, Cancer Institute (WIA), Zhongshan Hospital
- RHRun Huang
Ministry of Education of the People's Republic of China, Chinese Academy of Medical Sciences & Peking Union Medical College, Fudan University, Cancer Institute (WIA), Zhongshan Hospital
- WQWei‐Feng Qu
Ministry of Education of the People's Republic of China, Chinese Academy of Medical Sciences & Peking Union Medical College, Fudan University, Cancer Institute (WIA), Zhongshan Hospital
- YFYuan Fang
Ministry of Education of the People's Republic of China, Chinese Academy of Medical Sciences & Peking Union Medical College, Fudan University, Cancer Institute (WIA), Zhongshan Hospital
Topics & keywords
- Tumor microenvironment
- CD36
- Macrophage migration inhibitory factor
- Cancer research
- Cancer-Associated Fibroblasts
- Immunotherapy
- Immune system
- Biology
Funding
- NNNational Natural Science Foundation of ChinaAwards: 82073218, 2018YFC1312100, 82073217, 2018SHZDZX05, 82003084, 81773067
- SYSun Yat-sen University
- FUFudan University
- CAChinese Academy of Medical SciencesAward: 2018YFC1312100
- SUShanghai University of Traditional Chinese Medicine
- NKNational Key Research and Development Program of ChinaAwards: 2018YFC1312100, 2018SHZDZX05