Molecular mechanisms of ferroptosis and their involvement in brain diseases
Universidade do Porto · Cooperativa de Ensino Superior Politécnico e Universitário · +1 more institution
Abstract
Ferroptosis is a type of regulated cell death characterized by intracellular accumulation of iron and reactive oxygen species, inhibition of system Xc-, glutathione depletion, nicotinamide adenine dinucleotide phosphate oxidation and lipid peroxidation. Since its discovery and characterization in 2012, many efforts have been made to reveal the underlying mechanisms, modulating compounds, and its involvement in disease pathways. Ferroptosis inducers include erastin, sorafenib, sulfasalazine and glutamate, which, by inhibiting system Xc-, prevent the import of cysteine into the cells. RSL3, statins, Ml162 and Ml210 induce ferroptosis by inhibiting glutathione peroxidase 4 (GPX4), which is responsible for…
Citation impact
- FWCI
- 84.65
- Percentile
- 100%
- References
- 254
Authors
8- ICInês CostaCorresponding
Universidade do Porto
- DJDaniel José Barbosa
Cooperativa de Ensino Superior Politécnico e Universitário, i3S - Instituto de Investigação e Inovação em Saúde, Universidade do Porto
- SBSofia BenfeitoCorresponding
Universidade do Porto
- VSVera Silva
Universidade do Porto
- DCDaniel Chavarria
Universidade do Porto
Topics & keywords
- GPX4
- Lipid peroxidation
- Chemistry
- Nicotinamide adenine dinucleotide phosphate
- Reactive oxygen species
- Programmed cell death
- Cancer research
- Pharmacology
- Good health and well-being