Photon-Controlled Pyroptosis Activation (PhotoPyro): An Emerging Trigger for Antitumor Immune Response

Pyroptosis refers to the process of gasdermin-mediated lytic programmed cell death (PCD) characterized by the release of pro-inflammatory cytokines. Our knowledge of pyroptosis has expanded beyond the cellular level and now includes extracellular responses. In recent years, pyroptosis has attracted considerable attention due to its potential to induce host immunity. For instance, at the 2022 International Medicinal Chemistry of Natural Active Ligand Metal-Based Drugs (MCNALMD) conference, numerous researchers demonstrated an interest in photon-controlled pyroptosis activation ("PhotoPyro"), an emerging pyroptosis-engineered approach for activating systemic immunity via photoirradiation. Given this enthusiasm,…

• WF
  Welch Foundation

  Award: F-0018
• NR
  National Research Foundation
• NR
  National Research Foundation of Korea

  Award: 2020H1D3A1A02080172
• MO
  Ministry of Science and ICT, South Korea

  Award: 2018R1A3B1052702
• NI
  National Institutes of Health

  Award: CA68682
• NC
  National Cancer Institute

  Award: CA68682