Polymer- and lipid-based nanocarriers for ocular drug delivery: Current status and future perspectives

Ocular diseases seriously affect patients' vision and life quality, with a global morbidity of over 43 million blindness. However, efficient drug delivery to treat ocular diseases, particularly intraocular disorders, remains a huge challenge due to multiple ocular barriers that significantly affect the ultimate therapeutic efficacy of drugs. Recent advances in nanocarrier technology offer a promising opportunity to overcome these barriers by providing enhanced penetration, increased retention, improved solubility, reduced toxicity, prolonged release, and targeted delivery of the loaded drug to the eyes. This review primarily provides an overview of the progress and contemporary applications of nanocarriers,…

• NN
  National Natural Science Foundation of China

  Awards: 22005265, 82271064, 82271063, 82201158, 52203191, 82070939
• SP
  Shanxi Provincial Key Research and Development Project

  Award: 2020C03035
• NS
  Natural Science Foundation of Zhejiang Province

  Award: LR23H120001