Cuproptosis: mechanisms and links with cancers

Cuproptosis was a copper-dependent and unique kind of cell death that was separate from existing other forms of cell death. The last decade has witnessed a considerable increase in investigations of programmed cell death, and whether copper induced cell death was an independent form of cell death has long been argued until mechanism of cuproptosis has been revealed. After that, increasing number of researchers attempted to identify the relationship between cuproptosis and the process of cancer. Thus, in this review, we systematically detailed the systemic and cellular metabolic processes of copper and the copper-related tumor signaling pathways. Moreover, we not only focus on the discovery process of…

• NN
  National Natural Science Foundation of China

  Awards: 2021-PT310-001, 2021-I2M-1-012, Z191100006619118, -I2M-1-012, 2021B0101420005, KY201701, 2021YFC2501900, 82188102, 2021-I2M-1-067, KJZD20191002302, 82122053, 82122053, 82188102, 2021-RC310-020
• CA
  Chinese Academy of Medical Sciences

  Awards: 2021-PT310-001, 2021-RC310-020, 2021B0101420005, 2021-I2M-1-012, 2021-I2M-1-067, 2021YFC2501900, KY201701, KJZD20191002302, Z191100006619118, 82122053, 82188102
• SP
  Sanming Project of Medicine in Shenzhen

  Awards: 82122053, 2021-I2M-1-067, 2021-PT310-001, 2021-I2M-1-012, Z191100006619118, 2021B0101420005, 2021-RC310-020, 2021YFC2501900
• NK
  National Key Research and Development Program of China

  Award: 2021YFC2501900
• SP
  Special Project for Research and Development in Key areas of Guangdong Province

  Award: 2021B0101420005