The Bidirectional Gut–Lung Axis in Chronic Obstructive Pulmonary Disease

Abstract Epidemiological studies indicate that chronic obstructive pulmonary disease (COPD) is associated with the incidence of changes in intestinal health. Cigarette smoking, as one of the major causes of COPD, can have an impact on the gastrointestinal system and promotes intestinal diseases. This points to the existence of gut–lung interactions, but an overview of the underlying mechanisms of the bidirectional connection between the lungs and the gut in COPD is lacking. The interaction between the lungs and the gut can occur through circulating inflammatory cells and mediators. Moreover, gut microbiota dysbiosis, observed in both COPD and intestinal disorders, can lead to a disturbed mucosal environment,…

• CS
  China Scholarship Council

  Award: 201706170055
• FR
  Fundamental Research Funds for the Central Universities

  Award: 1124007125