Endothelial dysfunction due to eNOS uncoupling: molecular mechanisms as potential therapeutic targets
Gdańsk Medical University · Maj Institute of Pharmacology · +6 more institutions
Abstract
Abstract Nitric oxide (NO) is one of the most important molecules released by endothelial cells, and its antiatherogenic properties support cardiovascular homeostasis. Diminished NO bioavailability is a common hallmark of endothelial dysfunction underlying the pathogenesis of the cardiovascular disease. Vascular NO is synthesized by endothelial nitric oxide synthase (eNOS) from the substrate L-arginine (L-Arg), with tetrahydrobiopterin (BH 4 ) as an essential cofactor. Cardiovascular risk factors such as diabetes, dyslipidemia, hypertension, aging, or smoking increase vascular oxidative stress that strongly affects eNOS activity and leads to eNOS uncoupling. Uncoupled eNOS produces superoxide anion (O 2 − )…
Citation impact
- FWCI
- 45.14
- Percentile
- 100%
- References
- 265
Authors
5- AJAnna Janaszak‐JasieckaCorresponding
Gdańsk Medical University
- APAgata Płoska
Gdańsk Medical University
- JMJoanna M. Wierońska
Maj Institute of Pharmacology, Polish Academy of Sciences
- LWLawrence W. Dobrucki
Carle Foundation Hospital, University of Illinois Urbana-Champaign, Illinois College, Urbana University, Gdańsk Medical University
- LKLeszek Kalinowski
Gdańsk University of Technology, Gdańsk Medical University
Topics & keywords
- Enos
- Tetrahydrobiopterin
- Endothelial dysfunction
- Oxidative stress
- Nitric oxide
- Internal medicine
- Endocrinology
- Pathogenesis
- Good health and well-being