Linoleic acid potentiates CD8+ T cell metabolic fitness and antitumor immunity
Istituti di Ricovero e Cura a Carattere Scientifico · European Institute of Oncology · +13 more institutions
Abstract
Nava-Lauson et al. report that linoleic acid potentiates antitumor function of CD8+ T cells by operating a profound metabolic reprogramming that protects from exhaustion and pushes toward a memory phenotype with superior cytotoxic functions. LA-redirected CD8+ T cells are empowered with an improved metabolic and functional fitness within the TME, thereby improving efficacy of ACT-based therapy.
Citation impact
- FWCI
- 43.04
- Percentile
- 100%
- References
- 138
Authors
28- CBCarina B. Nava Lauson
Istituti di Ricovero e Cura a Carattere Scientifico, European Institute of Oncology
- STSilvia Tiberti
Istituti di Ricovero e Cura a Carattere Scientifico, European Institute of Oncology
- PAPaola Antonia Corsetto
University of Milan
- FCFederica Conte
National Research Council, Istituto di Analisi dei Sistemi ed Informatica Antonio Ruberti
- PTPunit Tyagi
Istituti di Ricovero e Cura a Carattere Scientifico, European Institute of Oncology
Topics & keywords
- CD8
- Immunity
- Cytotoxic T cell
- Linoleic acid
- Biology
- Cell metabolism
- T cell
- Immunology
- Good health and well-being