The complex genetic architecture of Alzheimer's disease: novel insights and future directions
University of California, San Francisco · University of San Francisco · +1 more institution
Abstract
BACKGROUND: Alzheimer's disease (AD) is a complex multifactorial neurodegenerative disorder and the most common form of dementia. AD is highly heritable, with heritability estimates of ∼70% from twin studies. Progressively larger genome-wide association studies (GWAS) have continued to expand our knowledge of AD/dementia genetic architecture. Until recently these efforts had identified 39 disease susceptibility loci in European ancestry populations. RECENT DEVELOPMENTS: Two new AD/dementia GWAS have dramatically expanded the sample sizes and the number of disease susceptibility loci. The first increased total sample size to 1,126,563-with an effective sample size of 332,376-by predominantly including new…
Citation impact
- FWCI
- 101.70
- Percentile
- 100%
- References
- 60
Authors
6- SJShea J. AndrewsCorresponding
University of California, San Francisco, University of San Francisco
- AEAlan E. Renton
Icahn School of Medicine at Mount Sinai
- BFBrian Fulton‐Howard
Icahn School of Medicine at Mount Sinai
- APAnna Podlesny‐Drabiniok
Icahn School of Medicine at Mount Sinai
- EMEdoardo Marcora
Icahn School of Medicine at Mount Sinai
Topics & keywords
- Genetic architecture
- Genome-wide association study
- Dementia
- Disease
- Genetic association
- Heritability
- Alzheimer's disease
- Twin study