Current Advancements in Spinal Cord Injury Research—Glial Scar Formation and Neural Regeneration
Rutgers, The State University of New Jersey
Abstract
Spinal cord injury (SCI) is a complex tissue injury resulting in permanent and degenerating damage to the central nervous system (CNS). Detrimental cellular processes occur after SCI, including axonal degeneration, neuronal loss, neuroinflammation, reactive gliosis, and scar formation. The glial scar border forms to segregate the neural lesion and isolate spreading inflammation, reactive oxygen species, and excitotoxicity at the injury epicenter to preserve surrounding healthy tissue. The scar border is a physicochemical barrier composed of elongated astrocytes, fibroblasts, and microglia secreting chondroitin sulfate proteoglycans, collogen, and the dense extra-cellular matrix. While this physiological…
Citation impact
- FWCI
- 24.34
- Percentile
- 100%
- References
- 159
Authors
5- TCTanner Clifford
Rutgers, The State University of New Jersey
- ZFZachary Finkel
Rutgers, The State University of New Jersey
- BRBrianna Rodriguez
Rutgers, The State University of New Jersey
- AJAdelina Joseph
Rutgers, The State University of New Jersey
- LCLi CaiCorresponding
Rutgers, The State University of New Jersey
Topics & keywords
- Glial scar
- Regeneration (biology)
- Spinal cord injury
- Gliosis
- Lesion
- Neuroinflammation
- Excitotoxicity
- Microglia
- Good health and well-being